Studying Genetic Origins of Behaviour: Fruit Flies, Knockout Mice, Humans and Sleep
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Generation of global Spata19 knockout mouse using CRISPR/Cas9 nickase technology
Introduction: SPATA19 gene is expressed in developmental stages of testis and some organs, but so far its function has only been examined in the testis. In this study, we provided an effective pathway for the generation of these mice using new CRISPR / Cas9 nickase method while generating Spata19 knockout mice for future studies in other organs. Materials and Methods: CRISPR / Cas9 nickase plas...
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STUDY OBJECTIVES Physiological studies show that aging affects both sleep quality and quantity in humans, and sleep complaints increase with age. Along with knowledge about the negative effects of poor sleep on health, understanding the enigmatic relationship between sleep and aging is important. Because human sleep is similar to Drosophila (fruit fly) sleep in many ways, we addressed the effec...
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Many studies in diverse organisms, including humans, have demonstrated a fundamental role for sleep in the formation of memories. A new study by Berry et al. indicates that, in fruit flies, sleep accomplishes this in part by preventing an active process of forgetting.
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Gap junction proteins mediate electrical synaptic transmission. In Drosophila, flies carrying null mutations in the shakB locus, such as shakB 2 , have behavioral and electrophysiological defects in the giant fiber (GF) system neurocircuit consistent with a loss of transmission at electrical synapses. The shakB 2 mutation also affects seizure-susceptibility. Mutant flies are especially seizure-...
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